![]() A built-in non-custodial wallet will initially support Ethereum in beta but will soon extend interoperability across the major networks and naming systems through partnerships with Polygon, Solana, Nervos, Celo, Unstoppable Domains, Handshake, ENS, and many more to be announced. These include direct access to decentralized exchanges, Web3-based NFTs, and gaming Dapps as well as integrated Telegram and Twitter support - accessed directly from the browser’s sidebar. “We are releasing our beta to the world to get feedback from the crypto community and to build it together moving forward,” added Arnesen. Opera believes Web3 has to be easy to use for the decentralized web to reach its full potential.” It simplifies a Web3 user experience that is often bewildering for mainstream users. Opera’s Crypto Browser Project promises a simpler, faster, more private Web3 experience for users. Jorgen Arnesen, EVP Mobile at Opera, says: “ The interest in Web3 continues to grow but none of the existing web browsing experiences offered today are built to create a seamless and secure user experience in the decentralized web. The crypto browser integrates these same industry-leading standards and services with a new set of novel features that make using the new blockchain-based web as simple as accessing Web2. The Opera browser is already one of the most secure privacy browsers in the world, thanks to its no-login VPN, and native ad & tracker blocker. The browser comes equipped with a news and data aggregator, dubbed “Crypto Corner” - a dedicated space with key information including crypto news, crypto asset prices and gas fees, in addition to crypto events, airdrops and even podcasts. With its crypto browser project, Opera intends to make it easier than ever to browse decentralized apps (dapps), games, and metaverse platforms for a more seamless cross-platform experience. The new beta offering caters to the crypto-native and the crypto-curious, placing Web3 front and center in the browsing experience. ![]() Oslo, Norway, Opera, the company behind the popular, eponymous multi-platform web browser, today unveils its “Crypto Browser Project,” offering users direct, frictionless access to Web3 services with beta versions immediately available for Windows, Mac and Android. Shipping today in beta to Windows, Mac and Android Opera’s fast and secure Web3 browser is easy to use and offers a built-in non-custodial wallet. Opera announces beta of a new Web3-Browser With Built-In Crypto Wallet
0 Comments
8/12/2023 0 Comments A path towards the stars![]() ![]() Desperate to save Star Flower, Clear Sky must convince the other groups-led by Tall Shadow, Wind Runner, Thunder, and River Ripple-to join forces, or their new way of life may not survive. ![]() But now the dangerous rogue Slash has kidnapped Clear Sky's mate, Star Flower, and made demands for prey that the cats cannot afford to meet. The sixth book in the Dawn of the Clans series takes readers back to the earliest days of the Clans, when the cats first settled in the forest and began to forge the warrior code.Īfter moons of strife, the forest cats have settled into five camps. You will download this as a PDF file which can be printed as is, but I also have provided a link on the first page that will give you access to an editable version via google drive.Discover the origins of the warrior Clans in this thrilling prequel to Erin Hunter's #1 nationally bestselling Warriors series Project Menu: 9 differentiated project ideas in a menu format as well as individual worksheets for each project But even at that high rate, it still takes us about 230 million years to make one complete orbit around the Milky Way The Milky Way is a spiral galaxy. Though all objects rotate in the sky, the observed path stars make. More accurately put, when looking north, objects in the sky move counter-clockwise. For an observer on the earth, objects move from east to west (this is true for both northern and southern hemispheres). We are moving at an average velocity of 828,000 km/hr. Viewed from above the north pole, the earth is rotating counter-clockwise. There is a cumulative twenty-item multiple choice test at the end of the novel study.Ĥ. Answer: Yes, the Sun - in fact, our whole solar system - orbits around the center of the Milky Way Galaxy. Each of the four sections has a test with 10 multiple choice questions. If you observe an object near the horizon, you are looking through a path with the maximum amount of atmosphere between you and the object, so the seeing will be bad and the stars will be blobs larger than 1 arcsecond. ![]() Comprehension: Options for discussion questions (free response) in written or group settings. We are each responsible for our own fate, and with help from others, we can achieve success if we plan well and work hard, Sylvia. The effect of the atmosphere on our view of the sky is called seeing, and it varies by location on the sky and over time. Elements of literature: Worksheets include activities for Characterizations, Setting, Theme, Cause & Effect, Making Connections, and Plot Mountain.ģ. Pages are approximations since online and print versions of this book can vary slightly.Ģ. Vocabulary: Using my personal Frayer Model, students focus on key vocabulary. But now the dangerous rogue Slash has kidnapped Clear. Throughout the packet, students will encounter:ġ. It will almost certainly clip the outskirts of the solar system and send comets towards Earth though not for a while. After moons of strife, the forest cats have settled into five camps. Our story begins lightyears away, deep in the heart of a sun-like star, where gravity’s immense inward pressure keeps temperatures high and atoms disassembled. This novel study can be used for assessments, discussions, whole or small groups, homework, extension activities, or regular class assignments. PATH TO THE STARS My Journey From Girl Scout To Rocket Scientist by Sylvia Acevedo is a biographical story depicting a girl who challenged norms and learned at every opportunity. This printable, no-prep book study is comprised of literacy activities and worksheets, assessments, graphic organizers and project ideas to increase student reflection and encourage thoughtful discussions. This Common Core-aligned teaching guide for Path the Stars by Latinx scientist Sylvia Acevedo includes numerous individual and group activities sure to. ![]() Definitely not boring tho and definitely not a "chick flick". ABBREVIATIONS ANAGRAMS BIOGRAPHIES CALCULATORS CONVERSIONS. Youve seen the difference and its getting better all the time. Movie soundtracks to I Melt With You by Modern English from the Ultimate Power of Supergroups album Login. Never really knowing it was always mesh and lace. Nicolas Cage ('Vampire's Kiss') and Deborah Foreman ('The Destroyer') star in the totally awesome comedy 'Valley Girl' When Julie (Foreman). ![]() I saw the world rushing all around your face. If you do, the movie becomes a warning or a dark fantasy or something else. Making love to you was never second best. if you don't, the movie might seem awfully self indulgent. Modern English - I Melt With You (Film Version) - YouTube Taken from the I Melt With You soundtrack for the Magnolia Pictures motion picture of the same name. You might see some of yourself in the characters- and you might not. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features NFL Sunday Ticket Press Copyright. Depending on how you look at the movie you might consider it a psych study on a group dynamic amongst males over time. It tells a story, the acting is good, the movie making is good, there are a few parts that are not completely clear- I'm not sure if that is writing or editing or directing. I don't usually write reviews but I felt like there was too much hate for this movie out there. I don't think this is necessarily a bad thing tho- people make movies for certain audiences all the time. If you don't fall into this demographic you probably are not going to dig this movie. I think it's pretty safe to say that the target market for this movie is over 40 and male (I might throw 'white' in there as well but I'm not sure about that). Modern English is known for Burlesque (2010), Don't Tell Mom the Babysitter's Dead (1991) and Stranger Things (2016). 8/12/2023 0 Comments Oscar wilde gay pioneerSwinburne was most likely autistic and suffered from seizures his entire life. This is another reason Swinburne was not well liked by many of his peers. Scott helped Swinburne recover from excessive alcohol while they were together, travelling to the French Riviera and throughout Italy, but Swinburne struggled with alcoholism most of his life. His grandfather died shortly after he left Balliol, and he stayed with his friend William Bell Scott in Newcastle. In part, this was due to a brief suspension in 1859 after publicly supporting an assassination attempt against Napoleon III. Some years later, he briefly attended Balliol College but ultimately left without a degree. He attended Eton College for some time, but poor health caused him to leave without finishing. ![]() But I believe it to be just.”ĭespite his poor health and small stature, he was fearless and driven, perhaps to the point of recklessness. It is but a child's impression of a child. Altogether my recollection of him in those school days is that of a fascinating, most loveable little fellow. All who knew him must remember that exquisitely soft voice with a rather sing-song intonation His language, even at that age, was beautiful, fanciful and richly varied. Another characteristic which Algernon inherited from his mother was the voice. His face was the very replica of that of his dear mother, and she was one of the most refined and lovely of women. His skin was very white - not unhealthy but a transparent tinted white, such as one sees in the petals of some roses. His features were small and beautiful, chiselled as daintily as those of some Greek sculptor's masterpiece. ![]() Red, violent, aggressive red it was,, unpoetical carrots. At that time there was nothing golden about it. Hero-worshippers talk of his hair as having been a 'golden aureole'. His limbs were small and delicate and his sloping shoulders looked far too weak to carry his great head, the size of which was by the tousled mass of red hair standing almost at right angles to it. “What a fragile little creature he seemed as he stood there between his father and mother, with his wondering eyes fixed upon me! Under his arm he hugged Bowdler's Shakespeare, a very precious treasure, bound in brown leather, with, for a marker, a narrow slip of ribbon, blue I think, with a button of that most heathenish marqueterie called Tunbridge ware dangling from the end of it. His cousin, Lord Redesdale, recalled a moment from their childhoods as such: He was a nervous, frail child, likely related to the fact that he was epileptic. He was the first of six children born to a wealthy Northumbrian family. Oscar Wilde called Swinburne “a braggart in matters of vice, who had done everything he could to convince his fellow citizens of his homosexuality and bestiality without being in the slightest degree a homosexual or a bestialiser.” While it’s true, Swinburne often encouraged and even started rumours about himself, sometimes to draw attention and other times for humour, his sexuality was anything but.Īlgernon Charles Swinburne was born in London in the spring of 1837. Algernon Charles Swinburne was not one to hide who he was, nor was he quiet about his beliefs. However, it is those queer people who abandon respectability who provoke change. They draw contempt from inside and outside of the community. There is a demand for queer people to be respectable, please the dominant society, conform, and hide that which is seen as other. All I can say of you or them-is that God made you, and that you are very wonderful and beautiful.” - John Ruskin in a letter to Swinburne ![]() I should as soon think of finding fault with you as with a thundercloud or a nightshade blossom. “For the matter of it-I consent to much-I regret much-I blame or reject nothing. 8/12/2023 0 Comments Symptoms of barotrauma earIn this way, no air is blown out but you are gently pushing air into the Eustachian tube. Then, try to breathe out gently with your mouth closed and pinching your nose (the Valsalva manoeuvre). For babies, it is a good idea to feed them or give them a drink at the time of descent to encourage them to swallow. Air is more likely to flow up the Eustachian tube if you swallow, yawn or chew. Suck sweets when the plane begins to descend.The following may help people who develop ear pain when flying. However, not many people will cancel their holiday trips for this reason. Ideally, anyone with a cold, respiratory infection, ear infection, etc, should not fly. In fact, any condition causing extra mucus in the back of the nose can cause this problem. The common cause of a blocked Eustachian tube is from mucus and inflammation that occur with colds, throat infections, hay fever, etc. Also, if you have any condition that causes a blockage to the Eustachian tube, then the air cannot travel up or down. For example, some people may have a more narrow Eustachian tube than normal. However, the Eustachian tube in some people does not open as easily and so the pressure may not be equalised so quickly. ![]() So, in most people, just normal swallowing and chewing allows air to flow up or down the Eustachian tube to quickly equalise the air pressure either side of the eardrum. The Eustachian tube is normally closed but opens from time to time when we swallow, yawn or chew. Why are some people affected more than others? Other situations where air pressure may quickly rise outside the ear is during scuba diving, diving to the bottom of a swimming pool, or rapidly descending in a lift (elevator). If the pressure inside the middle ear is not equalised quickly, then you can get ear pain. As a plane descends to land, the air pressure becomes higher nearer the ground. The most common example of barotrauma occurs to some air travellers. Air needs to travel up the Eustachian tube into the middle ear to equalise the pressure. ![]() To relieve the tensed eardrum, the pressure inside the middle ear has to rise quickly too. The tensed eardrum also cannot vibrate as well as it should and so you may also have dulled hearing. If the air pressure outside the ear quickly increases then this pushes the eardrum inwards which can be painful. The air on either side of the eardrum should be at the same pressure for the eardrum to vibrate and function normally. This air space is connected to the back of the nose by a tiny channel called the Eustachian tube. The small space in the middle ear behind the eardrum should normally be filled with air. Barotrauma of the ear is the most common type of barotrauma. Barotrauma means damage to tissues caused by a difference in pressure between an air space inside the body. It is where you have ear pain and dulled hearing because of unequal pressure that develops between the air in the middle ear and the air outside the ear. 8/12/2023 0 Comments Mgs snake escapeIf Snake uses his Revival Pill at this point, he will come back to life, in the real world. But here’s the thing – this gives you an opportunity to escape. You may be able to dodge some of his attacks but there is no way to effectively counter-attack. The soldiers cling to Snake, the man who took their lives.Įvery now and then the Sorrow launches a spiraling projectile at you. Their voices are full of fear and agony – sensations caused by you. Their appearances betray how you’ve ended their lives, and up to a 100 bodies can come back to haunt you during this scene. ![]() But they’re not random ghosts – each and every one of them represents a soldier you’ve killed during your mission. Soldiers stumble past you, throats slit and bloody. The ghosts of soldiers, the ghosts of defeated Cobra unit members, even perished animals. Besides, his gauge is already depleted – he has already died, after all.Īs you move through the river, other ghosts start to appear. Attacking the Sorrow is useless, he is a ghost and bullets go straight through him. “Light and dark are brewing within you.” he says, prophesying later events in the saga. As you plow forward, you can see the Sorrow moving along with you in the fog, a few meters in front of you, or circling you. The Sorrow disappears, and control is returned to the player. “Now you will know the sorrow of those whose lives you’ve ended.” he says with a grim voice. “The dead are not silent.” A tear of blood rolls from his eye. ![]() But make no mistake…” He firmly points his finger at Snake. “The living may not hear them.” the Sorrow continues. This whole time Snake keeps his gun pointed at the levitating man. ![]() He removes his hood, and reveals his pale, but commanding face. “And you are one of them.” he proclaims, pointing at Snake. His voice is soft and subdued, but decisive at the same time. Suddenly, it starts to rain, and the fire quickly dies out.Ī gloomy figure rises above the surface, his back turned to Snake. Snake begins to move forward, wading against the stream. The mangrove is burning, forming a tunnel of flames across the water. However, he ends up having to jump into a river several hundred meters below.Īfter throwing himself into the depths, Snake finds himself standing in the waist-deep water of a mangrove river. Using one of various methods, he is able to escape, and manages to get away through the sewers. At a certain point in Metal Gear Solid 3, Snake is captured by Volgin and locked inside one of the cells inside the fortress of Grozny Grad. 8/11/2023 0 Comments Gish furniture lancaster paShow details and pay-what-you-will tickets can be found at /newsies or by calling 71. On the campus of Lancaster Bible College (901 Eden Rd, Lancaster, PA 17601)Īll shows are Pay-What-You-Will in keeping with Servant Stage’s mission to make exceptional performances accessible to everyone! Based on the 1992 motion picture and inspired by a true story, this family-friendly musical features high-energy dancing, a Tony-winning score by Alan Menken, and a timeless message to fight for what’s right and seize the day! ![]() Servant Stage brings the Broadway musical Newsies to Lancaster Bible College June 3rd-19th! When a ragtag group of newsboys are pushed too far by titans of industry, they band together to challenge the powerful. Ultimately, they want to serve others, just as Christ serves us. This community clinic desires each patient to experience real sustainable healing in their lives, offering holistic care in a loving environment. The pandemic pushed us outside, but your feedback on how great the experience was, has kept us outside under the stars for the evening.Īll proceeds from Top Chefs go to Water Street Health Services, a ministry of Water Street Mission, as they provide medical, dental and behavioral health care, to men, women and children experiencing homelessness in Lancaster County. This year, Top Chef will take place in a luxury tent, at the Lancaster Country Club. The night will not only highlight local cuisine but feature both a silent auction full of creative takeaway packages as well as an exciting live auction with several luxury getaways. Chef Cedric Barberet of Bistro Barbaret.Chef Tanner Seipp of Lancaster Country Club.Chef Daniel LeBoon of The Belvedere, Josephine’s, and C’est La Vie. ![]() The evening’s all-star lineup will include: Local, farm-fresh, and inventive, this evening will feature a spread of fantastic dishes prepared by local chefs, which celebrate Lancaster’s most creative cuisine. ![]() Not great, but not bad – enough to sustain the game's ongoing operations. Launch numbers seemed great! August numbers were… good. Here's some of what J Todd Coleman wrote at the time: Watch on YouTube The launch trailer for Crowfall.Ĭrowfall was sold to Monumental six months after release, and it was at that point that J Todd Coleman, the director of the game - and one of the two people who birthed the idea and successfully crowdfunded it - stepped away. ![]() There are some other particulars you can read on the Crowfall website. The service will go dark from 22nd November (11am CST). We have yet to determine what that looks like, but we are investing in and rethinking every part of the game - from the core technology and tools to art, design, and gameplay. " We're going to use this time to map out the future of the game. In order to refocus our efforts from live operations to development, we have decided to take the Crowfall live service offline for the time being. One of the biggest challenges has been the sheer amount of development effort required to build new campaigns and keep the game running daily. The announcement read: "Over the past few months, we've been evaluating the current state of Crowfall. In this article, I talk to Monumental about the decision and what it could mean. I cannot ever remember an MMO ever doing something similar. Crowfall has struggled since launch, and it was sold to Monumental in December 2021 partly because of this - because it needed significant change. Game operator Monumental said this was because it didn't have the headspace or resources to rethink the game while it was running it, and suggested Crowfall could return looking quite different indeed. There's no word on how long this will take, only that "nothing is off the table" in terms of what potentially may change. Earlier this week we heard the unusual news that player-versus-player MMO Crowfall, which launched in the summer of 2021, will be taken offline and taken back to the drawing board, where it will be rethought. 8/11/2023 0 Comments 80s boombox![]() ![]() In the 80s in fact, the boombox quickly became associated with urban society, particularly African American and Hispanic youth, and the wide use of the radio eventually gave way to the pejorative term “ghetto blaster”, as well as even more politically incorrect appellatives. Though today the boombox is more of a symbol of the 80s and early 90s, being referenced for example by artists like Madonna in her Hung Up (2005) and “Sorry” (2006) videos as well as featuring in Lady Gaga’s 2008 “Just Dance”, the boombox has a much stronger association with that period in terms of cultural and musical history than just a portable radio. With the change in musical genres and the boombox’s ubiquitous presence on the streets, over time, these portable radios became increasingly larger, some even reaching the size of a suitcase. Initially introduced to the American market during the mid-1970s, the boombox’s popularity surged in the 80s, becoming almost a status symbol. The name of the portable, battery operated radio/cassette player was partly due to its heavy, box like aesthetic, and its bass enhancing power speakers (boom). Here’ s more.īefore portable speakers, before the ipod, before the Walkman and MP3 players there was the boombox. But the boombox has always been a status symbol. The Boombox, the portable radio which provided the soundtrack to urban areas in the 80s and 90s, is enjoying a renaissance in fashion. 8/11/2023 0 Comments Cytosol and er lumen![]() The retention signal is recognized by specific receptors present in the ER and cis-GA, which retrieve the protein from post-ER compartments and return them to the ER by a retrograde translocation in COPI-coated vesicles. These proteins are typically marked with specific peptide tags, which distinguishes them from the proteins destined for secretion. However, not all proteins that enter the ER are secreted-some proteins exert their function inside the ER and thus need to be retained there or recycled between the ER and the post-ER compartments. Early in their synthesis, an N-terminal or, alternatively, an internal signaling sequence on the newly forming protein marks the protein to be directed towards the ER lumen, where it passes through to GA in Coat-protein complex II (COPII)-coated vesicles 12, 13. The best characterized of these is the conventional protein secretion (CPS) pathway, where proteins pass through the endoplasmic reticulum, towards the Golgi apparatus (GA), the trans-GA, and subsequently to the plasma membrane 2. While the aforementioned cells contain specialized granules and machinery, capable of exporting proteins in response to a defined signal, most, if not all, eukaryotic cells possess the ability to secrete proteins from the cell through natural secretion pathways. Examples of such systems include the release of neurotransmitters into the synaptic cleft 10 and insulin secretion from β-cells in the pancreas triggered by the increased concentration of glucose 11. Natural processes, which need to respond rapidly to changes in the environment, often rely on the secretion of preformed proteins, stored in intracellular compartments and secreted quickly from the specialized cells by the regulated trafficking systems. The processes of transcription and translation initiated by these systems can require several hours before the POI is secreted to a functionally relevant concentration. These systems, while effective at regulating the production of proteins, are rather slow since they regulate gene expression rather than protein trafficking. Several attempts have been made to control protein secretion, mostly by utilizing the established systems which rely on the control of gene expression 6, 7, 8, 9. Regulated secretion of a protein of interest (POI) would offer a valuable tool for a diverse range of functions, such as hormonal release, homeostasis, immune defense, cytokinesis 2 and quorum sensing 3, as well as advanced therapeutic applications 4, 5. Indeed, it has been estimated, that out of the ~25,000 full-length open-reading frames (ORF) on the human genome, ~11% code for secretory proteins, with a further 20% for transmembrane proteins 1. Protein secretion is an important cellular mechanism to translocate soluble or membrane-bound proteins in order to respond to the changes in the cellular environment or signals from other cells, thus influencing a wide range of biological functions. Regulation of the ER escape represents a platform for the design of fast-responsive and tightly-controlled modular and scalable protein secretion system for mammalian cells. Its application was demonstrated on a chemically regulated therapeutic protein secretion and regulated membrane translocation of a chimeric antigen receptor (CAR) targeting cancer antigen. Design of orthogonal chemically-regulated split proteases enables the combination of signals into logic functions. Here we present two genetically encoded orthogonal regulatory secretion systems, which rely on the retention of pre-synthesized proteins on the ER membrane (membER, released by a cytosolic protease) or inside the ER lumen (lumER, released by an ER-luminal protease), respectively, and their release by the chemical signal-regulated proteolytic removal of an ER-retention signal, without triggering ER stress due to protein aggregates. An alternative regulation to provide faster response would be valuable. Response of protein secretion based on transcriptional control is rather slow, as it requires transcription, translation and transport from the endoplasmic reticulum (ER) to the plasma membrane via the conventional protein secretion (CPS) pathway. Secreted proteins, such as hormones or cytokines, are key mediators in multicellular organisms. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |